Chemical synthesis and screening of bicyclic peptide libraries

A compound of Formula I:

• wherein:
• A is benzene;
• p, q, and r are independently selected from 0, 1, and 2;
• B1, B2, and B3 are independently selected from O and NR1;
• wherein R1 is H, or substituted or unsubstituted C1-C5 alkyl;
• L1 is selected from substituted or unsubstituted C1-C6 alkyl, amino acid, and a linker to a solid phase support;
• L2 is selected from hydrogen, substituted or unsubstituted C1-C6 alkyl, amino acid, and a linker to a solid phase support;
• D is selected from substituted or unsubstituted C1-C6 alkyl, or amino acid residue;
• and
• Xm and Xn independently comprise a sequence of 1-10 amino acids.