Antimicrobial surface
AssigneesThe University of Birmingham, The Secretary of State for Defence of the United Kingdom of Great Britain and Northern Ireland
InventorsArtemis Stamboulis, Felicity Jane de Cogan, Robert Scott, Anna Frances Acushia Peacock
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Abstract
The invention relates to an antimicrobial surface, in particular a surface functionalised with a peptide comprising an antimicrobial moiety. The invention comprises a surface functionalised with a peptide comprising an antimicrobial moiety and a binder moiety, wherein the peptide is immobilized on the surface by electrostatic interactions between the binder moiety and the surface. Further provided is a medical device, a peptide and a method for the immobilization of a peptide.
Claims18
A surface functionalized with a first peptide comprising a first antimicrobial moiety, and a first binder moiety, the first binder moiety having a net negative charge, and a second peptide comprising a second antimicrobial moiety and a second binder moiety, wherein the first peptide is immobilized on the surface by electrostatic interactions between the first binder moiety and the surface, the second peptide is immobilized on the surface by covalent interactions between the second binder moiety and the surface and wherein the first and the second peptide differ from each other by at least one amino acid.
A peptide comprising an antimicrobial moiety, wherein the antimicrobial moiety comprises a sequence selected from the group consisting of RRIYGRGYIRR (SEQ ID NO:
- 28) and GRRRRRRGALAGRRRRRRGALAG (SEQ ID NO:
- 6).
A peptide comprising an antimicrobial moiety, wherein the antimicrobial moiety comprises a sequence selected from the group consisting of RRIYGRGYIRR (SEQ ID NO:
- 28), GTCIYQRLNAF (SEQ ID NO:30), and CISEKTTDGHC (SEQ ID NO:
- 33).
Dependencies are inferred from the claim text.