Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as PARP inhibitors

An oral dosage form comprising a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit PARP:

• wherein:
• RN is selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is independently optionally substituted with at least one substituent R12;
• X is selected from C, N, O, or S;
• m and n, which may be the same or different, are each an integer of 0, 1, 2, or 3;
• t is an integer of 0, 1, 2, or 3;
• R1, at each occurrence, is independently selected from halogen, CN, NO2, OR9, NR9R10, NR9COR10, NR9SO2R10, CONR9R10, COOR9, SO2R9, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is independently optionally substituted with at least one substituent R12;
• R2 is selected from hydrogen, COR9, CONR9R10, CO2R9, SO2R9, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is independently optionally substituted with at least one substituent R12;
• R3, R4, R5, R6, R7 and R8, which may be the same or different, are each independently selected from hydrogen, halogen, —NR9R10, —OR9, oxo, —COR9, —CO2R9, —CONR9R10, —NR9CONR10R11, —NR9CO2R10, —NR9SO2R10, —SO2R9, alkyl, alkenyl, cycloalkyl, aryl, heterocyclyl, alkynyl, or heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, and heteroaryl is independently optionally substituted with at least one substituent R12;
• or (R3 and R4), and/or (R4 and R5), and/or (R5 and R6), and/or (R6 and R7), and/or (R7 and R8), together with the atom(s) they are attached, form a 3- to 8-membered saturated, partially or fully unsaturated ring having 0, 1 or 2 heteroatoms independently selected from —NR13—, —O—, —S—, —SO— or —SO2-, and said ring is optionally substituted with at least one substituent R12;
• provided that
• when X is O, R5 and R6 are absent,
• when X is N, R6 is absent,
• when X is S, R5 and R6 are absent, or at least one of R5 and R6 is oxo,
• when one of R3 and R4 is oxo, the other is absent,
• when one of R7 and R8 is oxo, the other is absent, and
• when X is C and one of R5 and R6 is oxo, the other is absent;
• R9, R10, and R11, which may be the same or different, are each selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is independently optionally substituted with at least one substituent R12;
• R12 is selected from CN, halogen, haloalkyl, NO2, —NR′R″, —OR′, oxo, —COR′, —CO2R′, —CONR′R″, —NR′CONR″R′″, —NR′CO2R″, —NR′SO2R″, —SO2R′, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein R′, R″, and R′″ are independently selected from hydrogen, haloalkyl, alkyl, arylalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, or (R′ and R″), and/or (R″ and R′″) together with the atoms to which they are attached, form a 3- to 8-membered saturated, partially or fully unsaturated ring having 0, 1 or 2 additional heteroatoms independently selected from —NR13—, —O—, —S—, —SO— or —SO2-;
• and
• R13 is selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl,
• wherein the cycloalkyl is a hydrocarbon group selected from saturated or partially unsaturated cyclic hydrocarbon groups, comprising monocyclic, bicyclic or tricyclic groups, and comprising from 3 to 12 carbon atoms;
• wherein the heteroaryl is a group selected from:
• 5- to 7-membered aromatic, monocyclic rings comprising at least one heteroatom selected from N, O, or S, with the remaining ring atoms being carbon;
• 8- to 12-membered bicyclic rings comprising at least one heteroatom selected from N, O, or S, with the remaining ring atoms being carbon and wherein at least one ring is aromatic and at least one heteroatom is present in the aromatic ring;
• and
• 11- to 14-membered tricyclic rings comprising at least one heteroatom selected from N, O, or S, with the remaining ring atoms being carbon and wherein at least one ring is aromatic and at least one heteroatom is present in an aromatic ring;
• and
• wherein the heterocyclyl is a ring selected from 4- to 12-membered monocyclic, bicyclic or tricyclic, saturated or partially unsaturated rings, comprising at least one carbon atoms in addition to at least one heteroatom selected from oxygen, sulfur, or nitrogen;
• and a pharmaceutically acceptable carrier.