WDR5 inhibitors and modulators

A compound of formula (I),

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is hydrogen or C1-4alkyl;
• R2 is hydrogen, C1-6alkyl, C3-8cycloalkyl, or C3-8cycloalkyl-C1-3alkylene-;
• X1 is a bond;
• R3 is G1 or -L1-G2;
• G1 and G2 are C3-8cycloalkyl, 4- to 8-membered heterocyclyl, aryl, or heteroaryl, wherein G1 and G2 are optionally substituted with 1-5 substituents independently selected from the group consisting of halogen, cyano, C1-4alkyl, C1-4haloalkyl, —O—C1-4alkyl, —O—C1-4haloalkyl, OH, oxo, —C(O)C1-4alkyl, —C(O)C1-4haloalkyl, —NH2, —NH(C1-4alkyl), —N(C1-4alkyl)2, —NHC(O)C1-4alkyl, and —N(C1-4alkyl)C(O)C1-4alkyl;
• L1 is —C1-3alkylene-;
• R4a, at each occurrence, is independently hydrogen, halogen, cyano, C1-4alkyl, C1-4haloalkyl, —O—C1-4alkyl, or OH;
• R4b, at each occurrence, is independently hydrogen, halogen, or C1-4alkyl;
• or R4a and R4b together with the carbon to which they are attached form a C3-6cycloalkyl;
• n is 1 or 2;
• X2 is C(R4a)(R4b) or N(R5);
• R5 is hydrogen, C1-4alkyl, C1-4haloalkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-3alkylene-, —C(O)C1-4alkyl, —C(O)C3-6cycloalkyl, or —C(O)OC1-4alkyl;
• R6a, R6b, R7a, R7b, R8a, and R8b are each hydrogen;
• and
• R9, R10, and R11 are each hydrogen.