US 10,501,462 B2 · Pyrrolo[3,2-c]pyridine-6-amino derivatives

Abstract

The present invention relates to novel pyrrolo[3,2-c]pyridine-6-amino derivatives that inhibit the spindle checkpoint function of Monospindle 1 (Mps1—also known as TTK) kinases. In particular, the present invention relates to isopropyl 6-(2-methoxy-4-(1-methyl-1H-1,2,3-triazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate and isopropyl 6-(2-methoxy-4-(1-methyl-1H-tetrazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate and their use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds and to pharmaceutical compositions comprising them.

Claims10

Dependent claims

A compound which is one of the following:

isopropyl 6-(2-methoxy-4-(1-methyl-1H-1,2,3-triazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;
or
isopropyl 6-(2-methoxy-4-(1-methyl-1H-tetrazol-5-yl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;
or a pharmaceutically acceptable salt or solvate thereof.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

16/064,297Filed 20 Dec 2016

Priority

GB 1522532.921 Dec 2015

Published

US 2019/0002462 A13 Jan 2019

Granted

10 Dec 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification4 codes

C07D 471/04
In which the condensed system contains two hetero rings: ortho-condensed systems
A61P 35/00
Antineoplastic agents
C07D
Heterocyclic compounds
A61P
Therapeutic uses of medicines

Pyrrolo[3,2-c]pyridine-6-amino derivatives

Life of this patent

Pyrrolo[3,2-c]pyridine-6-amino derivatives

Life of this patent

Abstract

Claims10