Monocyclic β-lactam-siderophore conjugate, and preparation method and use thereof

A monocyclic β-lactam-siderophore conjugate represented by formula (I), an optical isomer thereof or a pharmaceutically acceptable salt thereof:

• wherein X=CY or N, Y is H or a halogen;
• R is
• (1) a carboxyl group, —COOR1 or —CONR2R3;
• (2) an unsubstituted C1-6 linear alkyl group, an unsubstituted C3-6 branched alkyl group, a C3-6 cycloalkyl group or an unsubstituted C2-7 alkenyl group;
• (3) a substituted C1-4 linear alkyl group or C3-6 branched alkyl group, wherein the substituent is a hydroxyl group, an amino group, a cyano group, —OR1, —SR1, —S(O2)R1, —NR2R3, and a halogen;
• (4) a substituted or unsubstituted phenyl group, wherein the substituent in the substituted phenyl group is 1 to 3 substituents independently selected from the group consisting of a hydroxyl group, a cyano group, —R1, —OR1, —NR2R3 and a halogen;
• or
• (5) a substituted or unsubstituted 5- or 6-membered heteroaryl ring group having 1 to 4 hetero atoms independently selected from the group consisting of N, S and O, wherein the substituent in the 5- or 6-membered heteroaryl ring group is independently selected from the group consisting of a hydroxyl group, a cyano group, —R1, —OR1, —NR2R3, and a halogen;
• R1 is a C1-6 linear alkyl group, a C3-6 branched alkyl group or a C3-6 cycloalkyl group;
• R2 and R3 are each independently a hydrogen, a C1-6 linear alkyl group, a C3-6 branched alkyl group or a C3-6 cycloalkyl group;
• the halogen is F, Cl, Br or I;
• preferably F, Cl or Br;
• a stereo configuration of an alpha carbon may be of S type or R type or (R, S) type.