Lactam compound derivative and application thereof

A compound of Formula I or a pharmaceutically acceptable salt or prodrug thereof:

• wherein,
• X is C, O, N or NH;
• Z is-(CH2)n—, which is unsubstituted or substituted by one or more substituents selected from the group consisting of alkyl, cyano, hydroxy and halogen, n is an integer of 2˜7;
• R1 and R2 are each independently hydrogen, linear or branched alkyl containing 1˜5 carbon atoms, wherein the alkyl is optionally substituted by one or more substituents selected from the group consisting of alkyl, cyano, hydroxy and halogen;
• R3 is hydrogen, halogen or linear or branched alkyl containing 1˜5 carbon atoms, wherein the alkyl is optionally substituted by one or more substituents selected from the group consisting of alkyl, cyano, hydroxy and halogen;
• P is CH or N;
• Ar is a group selected from the group consisting of formula II-VII:
• L and M are independently CH or N;
• Q is O or S;
• R6, R7 and R8 are each independently hydrogen, halogen, linear or branched alkyl containing 1˜5 carbon atoms, or alkoxyl containing 1˜5 carbon atoms, wherein the alkyl is optionally substituted by one or more substituents selected from the group consisting of alkyl, cyano, hydroxy and halogen, and wherein the alkoxyl is optionally substituted by one or more substituents selected from the group consisting of alkyl, cyano, hydroxy and halogen;
• R4, R5 are each independently hydrogen, halogenated C1-5 alkyl, methoxyl, ethoxyl or propoxy.