Substituted nitrogen containing compounds

A compound having the structure of Formula (I)

• or a salt thereof, wherein:
• R1 is:
• each W is independently NR1b or O;
• Z is a bond or CHR1d;
• X is independently N or CR1a, wherein X is N at only 0, 1, or 2 positions;
• each R1a is independently H, F, Cl, —OH, —CN, C1-3 alkyl, C1-3 fluoroalkyl, C3-6 cycloalkyl, C1-3 alkoxy, or C1-3 fluoroalkoxy;
• each R1b is independently H, C1-3 alkyl, C2-3 fluoroalkyl, C3-6 cycloalkyl
• R1c is independently H, deuterium, C1-4 alkyl, C1-4 fluoroalkyl, or C3-6 cycloalkyl;
• R1d is H, C1-3 alkyl, C1-4 fluoroalkyl, or C3-6 cycloalkyl;
• Y is —C(R6)2—, —C(R6)2—C(R6)2—, —C(O)—, —C(O)—C(R6)2—, —C(R6)2—C(O)—, or SO2—;
• V is —O—, —NR4—, —CR5R5—, —S—, —S(O)—, —SO2—, or —C(O)—;
• wherein if V is —O—, —S—, —S(O)—, —SO2—, or —C(O)—, then Y is not —SO2—, and wherein if V is —O—, —S—, or NR4, then Y is not C(R6)2, and wherein if V is —S(O)—, —SO2—, or C(═O)—, then Y is not —C(═O)—, —C(═O)—C(R6)2—;
• L1 is —C(R)2—, —C(O)—, or —C(R)2—C(R)2—;
• wherein R is independently H, F, OH, C1-3 alkyl, C1-3 hydroxyalkyl, C1-3 alkoxyalkyl, or C1-3 fluoroalkyl;
• wherein R is not —OH or F if it is attached to a carbon atom that is adjacent to a nitrogen atom:
• Ring B is phenyl, pyridinyl, pyrimidinyl, pyrrazolyl, thiazolyl, imidazolyl, triazolyl, tetrazolyl, oxadiazolyl, thiadiazolyl, isoxazolyl, isothiazolyl, pyrrolyl, pyrazinyl, oxazolyl, pyridazinyl, pyrrolidinyl, or imidazolidinyl;
• R2 is a C6-10 aryl, or a 5 to 10 membered heterocycle ring containing 1 to 4 heteroatoms selected from N, O, and S, the heterocycle ring optionally containing an oxo substitution, the aryl or heterocycle ring are substituted with 0-3 R2a;
• R2a is independently OH, ═O, CN, halo, C1-4 alkyl, C1-4 deuteroalkyl, C1-4 fluoroalkyl, C1-4 alkoxy, C1-4 deuteroalkoxy, C1-4 fluoroalkoxy, C3-6 cycloalkyl, C3-6 cycloalkoxy, C(═O)NR4bR4b, C(═O)C1-4 alkyl, SO2Re, NR4bSO2R4b, or a 4 to 6 membered heterocycle having 1, 2, 3, or 4 heteroatoms selected from O, S, and N, the heterocycle optionally containing an oxo substitution and is substituted with 0-3 R2b;
• R2b is independently C1-3 alkyl, C1-3 fluoralkyl, C1-3 hydroxyalkyl, C3-6 cycloalkyl, or C3-6 fluorocycloalkyl;
• R3a is H, halo, OH, CN, C1-3 alkyl, C1-3 hydroxyalkyl, C1-3 fluoroalkyl, C1-3 alkoxy, or C3-6 cycloalkyl, wherein if V is —O—, —NR4—, —S—, —S(O)—, —SO2—, or —C(═O)—, then R3a is not halo, and wherein if V is —O—, —NR4—, —S—, then R3a is not OH, CN;
• R3b is H, ═O, C1-3 alkyl, C1-3 hydroxyalkyl, C1-3 fluoroalkyl, C1-3 alkoxy, or C3-6 cycloalkyl;
• R4 is H, C1-3 alkyl, C2-3 fluoroalkyl, C2-3 hydroxyalkyl, CO2R4a, C(O)R4a, SO2R4a, C(O)N(R4bR4b), SO2N(R4bR4b), or OH;
• R4a is C1-3 alkyl, C1-3 fluoroalkyl, C3-6 cycloalkyl, C3-6 fluorocycloalkyl, C6-10 aryl or a 4 to 10 membered heterocycle having 1, 2, 3 or 4 heteroatoms selected from O, S, and N, the aryl or heterocycle being substituted with 0-3 R4c;
• R4b is independently H, C1-3 alkyl, C2-3 fluoroalkyl, C3-6 cycloalkyl, C3-6 fluorocycloalkyl, C6-10 aryl or a 4 to 10 membered heterocycle having 1, 2, 3 or 4 heteroatoms selected from O, S, and N;
• alternatively, 2 R4bs, along with the atom to which they are attached, join to form a 3 to 6 membered saturated ring containing an additional 0-2 heteroatoms selected from O, S, and N;
• R4c is independently H, F, Cl, or C1-3 alkyl;
• R5 is independently H, F, OH, C1-3 alkoxy, C1-3 fluoroalkoxy, C1-3 alkyl, C1-3 fluoroalkyl, C1-3 hydroxyalkyl, C3-6 cycloalkyl, C3-6 fluorocycloalkyl, NR5bR5b, O—R5c, or 2 R5s are ═O;
• wherein if one R5 is F, OH or NR5bR5b, then the other R5 is not OH, or NR5bR5b;
• R5b is independently H, C1-3 alkyl, C3-6 cycloalkyl, C(O)Ra, SO2Ra, or C(O)NRbRb;
• alternatively, 2 R5bs, along with the atom to which they are attached, join to form a 3 to 6 membered saturated ring containing 0-2 heteroatoms selected from O, S, or N;
• R5c is independently H, C1-3 alkyl, C3-6 cycloalkyl, or C(O)NRbRb;
• R6 is independently H, OH, F, C1-3 alkyl, C1-3 deuteroalkyl, C1-3 fluoroalkyl, C3-6 cycloalkyl, C3-6 fluorocycloalkyl, C1-3 alkoxy, C1-3 hydroxyalkyl, C1-3 hydroxydeuteroalkyl, C1-3 alkoxyalkyl, or C1-3 fluoroalkoxyalkyl, or NR6bR6b;
• wherein if one R6 on one carbon atom is F, OH or NR6bR6b, then the other R6 on the same carbon atom is not OH or NR6bR6b;
• R6b is independently H, C1-3 alkyl, C3-6 cycloalkyl, C(O)Ra, SO2Ra, or C(O)NRbRb;
• alternatively, 2 R6s along with the same atom to which they are attached can form a 3 to 6 membered saturated ring containing 0-2 heteroatoms selected from O, S, and N;
• Ra is independently H, C1-3 alkyl, C2-3 fluoroalkyl, C3-6 cycloalkyl, C3-6 fluorocycloalkyl, C6-10 aryl or a 4 to 10 membered heterocycle having 1, 2, 3, or 4 heteroatoms selected from O, S, and N;
• Rb is independently H, C1-3 alkyl, C2-3 fluoroalkyl, C3-6 cycloalkyl, C3-6 fluorocycloalkyl, C6-10 aryl or a 4 to 10 membered heterocycle having 1, 2, 3 or 4 heteroatoms selected from O, S, and N;
• alternatively, 2 Rb's along with the atom to which they are attached, join to form a 3 to 6 membered saturated ring, containing 0-2 heteroatoms selected from O, S, and N;
• each Rd is independently H, F, C1-3 alkyl, C1-3 fluoroalkyl, C1-3 alkoxy, C1-3 fluoroalkoxy, C1-3 hydroxyalkyl, C3-6 cycloalkyl, halo, OH, ═O, CN, OCF3, OCHF2, CHF2CF3, or C(O)NReRe;
• each Re is independently H, C1-3 alkyl, C2-3 fluoroalkyl, C3-6 cycloalkyl, C2-3 hydroxyalkyl, C2-3 alkoxyalkyl, C6-10 aryl, or a 5 to 10 membered heteroaryl having 1, 2, 3, or 4 heteroatoms selected from O, S, and N;
• alternatively, 2 Res along with the atom to which they are attached, join to form a 3 to 6 membered saturated ring, containing 0-2 heteroatoms selected from O, S, or N;
• and
• n is 0, 1, or 2.