Back to results
US 10,501,443 B2Granted
Pyridone compound as c-met inhibitor
AssigneeFujian Cosunter Pharmaceutical Co., Ltd.
InventorsXiongbin Xu, Gang Li, Charles Z. Ding, Lihong Hu, Guoping Hu, Jian Li, Shuhui Chen, Zhigang Chi, Kun Wang
Life of this patent
Estimating the term…
Abstract
Disclosed in the present invention is a type of pyridone compounds as c-met inhibitors, and specifically disclosed is a compound as shown in formula (I) or a pharmaceutically acceptable salt thereof.
Claims17
A compound represented by formula (I) or a pharmaceutically acceptable salt,
- R1 is selected from H or F;
- R2 is selected from H or CH3;
- while R2 is not H, the configuration of the carbon atom bonded to R2 is R or S;
- A is selected from the group consisting of phenyl, pyridyl, pyrazolyl, isoxazolyl, isothiazolyl and thiazolyl, each of which is optionally substituted by 1, 2 or 3 R3;
- R3 is selected from CN, halogen, C(═O)NH2, or is selected from the group consisting of C1-6 alkyl, C1-6 heteroalkyl, and C3-6 cycloalkyl, each of which is optionally substituted by 1, 2 or 3 R0;
- R0 is selected from F, Cl, Br, I, OH, CN, NH2, C(═O)NH2, or is selected from the group consisting of C1-3 alkyl and C1-3 heteroalkyl, each of which is optionally substituted by 1, 2 or 3 R′;
- R′ is selected from F, Cl, Br, I, CN, OH, NH2, CH3, CH3CH2, CF3, CHF2 or CH2F;
- the “hetero” in the C1-3 heteroalkyl or C1-6 heteroalkyl is selected from the group consisting of —O—, —C(═O)NR′—, —C(═O)NH—, —NR′—, and —NH—;
- in any of the above cases, the number of the heteroatom or the heteroatomic group is independently selected from 1, 2 or 3.
6 more elements
Dependencies are inferred from the claim text.