Substituted benzimidazoles as modulators of Ras signaling

A compound of the following formula:

• X1A is C—R;
• X2 is C—R6;
• X3 is C—R6;
• X4 and X5 together form
• or substituted or unsubstituted cyclic amine (provided that the term cyclic amine excludes piperazine and azetidine);
• R is unsubstituted or substituted with one or more independent R5, and is independently chosen from alkyl, cycloalkyl, phenyl, hydroxyl, heterocycloalkyl, cyclic amine, halogen, CF3, Cl, CONR3R4, aryl, heteroaryl, O—RA, O-alkyl-RA, O-aryl, O-heteroaryl, N—RA, N-aryl, N-heteroaryl, NHRA, NR2R3, heteroalkyl, benzyl, heteroaryl benzyl (CH2-heteroaryl), alkenyl, alkynyl, alkyl-cycloalkyl, CH2-cycloalkyl, CH2—CF3, hydroxyalkyl, alkyl-alkoxy, alkyl-cycloheteroalkyl, alkyl-heteroaryl, alkyl-carboxylic acid, CO—CF3, alkyl-CO—O-alkyl, alkyl-CO—NR3R4, CO-alkyl-sulfonyl-alkyl, CO-cycloheteroalkyl, CO—NH-cycloalkyl, CN, alkoxy-cycloalkyl, alkoxy-cycloheteroalkyl, O-alkoxy, O-dioxothian, alkoxy, O-heteroalkyl, alkoxy-heteroalkyl, methylsulfonyl, O-cycloheteroalkyl, O-alkoxy-cycloheteroalkyl, O-alkoxy-aryl, O-heteroaryl, NR3COR2, amino-cycloalkyl, amino-cycloheteroalkyl, NR3-alkoxy, NR3-dioxothian, NR3-heteroalkyl, amino-heteroalkyl, NR3-cycloheteroalkyl, NR3-cycloheteroalkyl, NR3-aryl, NR3-heteroaryl, NR3—CO—CF3, alkyl-CO—NR3R4, NR3—CO-alkyl-sulfonyl-alkyl, NR3—CO— cycloheteroalkyl, CO—NR3-cycloalkyl, alkyl-carboxylic acid, alkoxy-heteroaryl, alkyl-phenyl, cycloheteroalkyl, amino, amino-heteroaryl, amino-phenyl, CO-alkyl, CONR3-alkyl, CH3, NH2, alkyl-amino, pyridine, pyrazole, furan, thiophene, pyrimidine, thiazole, isothiazole, oxazole, isoxazole, piperazine, pyrrole, pyrazine, dioxane, morpholine, thiomorpholine, triazole, imidazole, alkoxy;
• RA is unsubstituted or substituted with one or more independent R5, and is independently chosen from H, alkyl, cycloalkyl, phenyl, hydroxyl, heterocycloalkyl, cyclic amine, halogen, CF3, Cl, CONR3R4, aryl, heteroaryl, O—R3, O-alkyl-R3, O-aryl, O-heteroaryl, N—R3, N-aryl, N-heteroaryl, NR2R3, heteroalkyl, benzyl, heteroaryl benzyl (CH2-heteroaryl), alkenyl, alkynyl, alkyl-cycloalkyl, CH2-cycloalkyl, CH2—CF3, hydroxyalkyl, alkyl-alkoxy, alkyl-cycloheteroalkyl, alkyl-heteroaryl, alkyl-carboxylic acid, CO—CF3, alkyl-CO—O-alkyl, alkyl-CO—NR3R4, CO-alkyl-sulfonyl-alkyl, CO-cycloheteroalkyl, CO—NH-cycloalkyl, CN, alkoxy-cycloalkyl, alkoxy-cycloheteroalkyl, O-alkoxy, O-dioxothian, alkoxy, O-heteroalkyl, alkoxy-heteroalkyl, methylsulfonyl, O-cycloheteroalkyl, O-alkoxy-cycloheteroalkyl, O-alkoxy-aryl, O-heteroaryl, NR3COR2, amino-cycloalkyl, amino-cycloheteroalkyl, NR3-alkoxy, NR3-dioxothian, NR3-heteroalkyl, amino-heteroalkyl, NR3-cycloheteroalkyl, NR3-cycloheteroalkyl, NR3-aryl, NR3-heteroaryl, NR3—CO—CF3, alkyl-CO—NR3R4, NR3—CO-alkyl-sulfonyl-alkyl, NR3—CO— cycloheteroalkyl, CO—NR3-cycloalkyl, alkyl-carboxylic acid, alkoxy-heteroaryl, alkyl-phenyl, cycloheteroalkyl, amino, amino-heteroaryl, amino-phenyl, CO-alkyl, CONR3-alkyl, CH3, NH2, alkyl-amino, pyridine, pyrazole, furan, thiophene, pyrimidine, thiazole, isothiazole, oxazole, isoxazole, piperazine, pyrrole, pyrazine, dioxane, morpholine, thiomorpholine, triazole, imidazole, alkoxy;
• R2 is substituted by one or more R5, or unsubstituted and is selected from H, alkyl, alkene, alkyne, alkyl-heteroaryl, alkyl-heterocycloalkyl, alkyl-amino, or together with R3 forms a 3-6 membered ring;
• R3 is substituted by one or more R5 or unsubstituted and is selected from H, alkyl, alkenyl, alkynyl, alkyl-heteroaryl, alkyl-heterocycloalkyl, alkyl-amino, or together with R2 forms a ring;
• R4 is substituted by one or more R5, or unsubstituted and is selected from benzyl, methylcycloalkyl, cycloalkyl, alkyl-cycloalkyl;
• R5 (i) appears once and is a halogen;
• (ii) appears twice and is
• two halogens,
• alkyl and halogen,
• CF3 and halogen;
• (iii) appears three times and is:
• a halogen, alkyl, and alkenyl,
• a halogen, a alkyl, and alkynyl,
• two alkyls and a halogen;
• or
• three halogens;
• R6 is independently selected from H, halogen, CH3, or CF3, provided that in connection with X2R6 is H or methyl, and in connection with X3, R6 is methyl, CF3, or halogen;
• or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable derivative thereof.