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US 10,501,419 B2Granted
Processes for the preparation of ivacaftor
AssigneeLaurus Labs Limited
InventorsSuresh Thatipally, Venkata Krishna Reddy, Venkata Lakshmi Narasimha Rao Dammalapati, Satyanarayana Chava
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Abstract
The present invention provides processes for the preparation of ivacaftor using novel intermediates and a process for its preparation.
Claims14
A process for the preparation of ivacaftor of Formula I or a pharmaceutically acceptable salt thereof,
- comprising:
- a1) reacting a compound of Formula VI with a dimethyl formamide-dimethyl amine complex to obtain a compound of Formula VII,
- wherein ‘X’ represents a halo and ‘R1’ represents either hydrogen or a protecting group;
- b1) reacting the compound of Formula VII with a source of ammonia to obtain a compound of Formula VIII,
- c1) cyclizing the compound of Formula VIII to obtain the ivacaftor of Formula I, when R1 is hydrogen, or to obtain a compound of Formula IX, when R1 represents a protecting group and deprotecting the Formula IX in a deprotecting agent to obtain the ivacaftor,
2 more elements
Dependencies are inferred from the claim text.