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US 10,501,414 B2Granted
Indole analogs as 5-oxo-ETE receptor antagonists and method of use thereof
AssigneesThe Royal Institution for the Advancement of Learning/Mcgill University, Florida Institute of Technology
InventorsWilliam S. Powell, Joshua Rokach
Life of this patent
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Abstract
This invention relates to novel pharmaceutically-useful compounds, to methods for their preparation, and to pharmaceutical compositions and therapeutic methods for treating certain conditions.
Claims14
A compound of formula
- or a pharmaceutically acceptable salt or solvate thereof;
- wherein
- R1 is H, a straight or branched alkyl, or lower cycloalkyl;
- R2 is a lower straight or branched alkyl or lower cycloalkyl;
- L is an alkylene chain of 4-7 members, an alkenylene chain of 4-7 members, a CH(OH)-alkylene chain wherein said alkylene chain in CH(OH)-alkylene chain has 4-6 members or an alkylene-O-alkylene chain wherein the two alkylene chains together in alkylene-O-alkylene chain have a total of 4-6 members;
- Rb is H or F;
- m is an integer of 0 to 5;
- X is a substituent;
- n is an integer of 0 to 4;
- and
- Ra is a substituent.
8 more elements
A compound as defined in table 2 or table 3:
- TABLE 2
- Compounds
- Formula
- 15
- 13
- 14
- 17
- 18
- 19
- 20
- 21
- 22
- 23
- 24
- 25
- 39
- 37
- 38
- 46
- 47
- 48
- 49
- 50
- 51
- 52
- 53
- 54
- 55
- 61
- 62
- 63
- 64
- 65
- 66
- 67
- 68
- 69
- 70
- 83
- 85
- 94
- 95
- 96
- 97
- 159
- or
- TABLE 3
- Com-
- pounds
- Formula
- 46M
- 50M
- 54M
- or
- 49M
52 more elements
Dependencies are inferred from the claim text.