Inhibitors of the Notch transcriptional activation complex and methods for use of the same

A method of inhibiting the Notch transcriptional activation complex (“NTC”) in a cell, comprising contacting the cell with a compound of Formula (I), or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit the NTC:

• wherein
• represents a bond that results in the adjacent double bond being in either the E or Z configuration;
• n is 0, 1, 2, 3, or 4;
• X is O or S;
• Y is O, S, NH, or NC1-3 alkyl;
• R1 is selected from the group consisting of H, C1-6 alkyl, C1-6 alkenyl, C0-6 alkylene—COR9, NH-aryl, NH—(C═O)-aryl, C0-6 alkylene-cycloalkyl, C0-6 alkylene-heterocycloalkyl, C0-6 alkylene-heterocycloalkenyl, C0-6 alkylene-aryl, C1-6 alkylene—SO2R5, C1-6 alkylene-R5, and C0-6 alkylene-heteroaryl;
• R2 is H or C1-3 alkyl;
• each R3 is independently selected from the group consisting of OR4, COOR4, NO2, halo, SO2R5, C1-6 alkyl, C1-6 alkenyl, C0-6 alkylene-cycloalkyl, C0-6 alkylene-aryl, C0-6 alkylene-heteroaryl, and (C═O)N(R7)2;
• R4 is selected from the group consisting of H, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, C0-6 alkylene-(C═O)R8, C1-6 alkylene-N(R6)2, C1-6 alkylene-CN, C0-6 alkylene-aryl, C0-6 alkylene-heteroaryl, C1-6 alkylene-O-aryl, C1-6 alkylene-S-aryl, C1-6 alkylene-NR6-aryl, and C1-6 alkylene-NR6-heteroaryl;
• R5 is OH, N(R6)2, NH(C═O)C1-3 alkyl, or NH(C═O)aryl;
• each R6 is independently H, C1-3 alkyl;
• each R7 is independently H, C1-3 alkyl, SO2H;
• or SO2(C1-3 alkyl);
• R8 is C1-6 alkyl, aryl, OC1-6 alkyl, or N(R6)2;
• and
• R9 is OH, N(R6)2, NHSO2R6, SO2N(R6)2.