Method for preparation of (S)-N1-(2-aminoethyl)-3-(4-alkoxyphenyl)propane-1,2-diamine trihydrochloride

A method for preparing (S)—N1-(2-aminoethyl)-3-(4-alkoxyphenyl)propane-1,2-diamine trihydrochloride, comprising the following steps:

• (1) preparing a compound of Formula 2 by Grignard coupling of a compound of Formula 1;
• (2) preparing a compound of Formula 3 by azide substitution of the compound of Formula 2 in a reaction with sodium azide;
• (3) preparing an aziridine derivative of Formula 4 having an amino group protected by an amino-protecting group by cyclization of the compound of Formula 3 using triphenylphosphine;
• (4) preparing a compound of Formula 5 by ring opening of the compound of Formula 4;
• (5) preparing a compound of Formula 6 by a reaction for removing the amino-protecting group of the compound of Formula 5:
• wherein X is bromo or chloro, and
• R is C1-6 alkyl.