Back to results
US 10,500,588 B2Granted
Microfluidic aliquot chip for single-cell isolation
AssigneeLidong Qin
InventorsLidong Qin, Kai Zhang
Life of this patent
Estimating the term…
Abstract
According to the invention, generally, a microfluidic aliquot (MA) chip, adapted to fit in a Petri dish, has a center well (inlet) connected by branched channels to a plurality of side wells (outlets). The chip comes in various types, including a bMA Chip T1, bMA Chip T2, bMA Chip T3, and an rMA Chip. The branched channel improvement provides for a greater distance between neighboring channels and a decreased density near the center well. An insert and a base are configured to create an MA chip.
Claims12
A microfluidic aliquot (MA) chip for isolating cells, comprising:
- a chip having a center, a top surface, a bottom surface, an outer edge and a thickness;
- an inlet well disposed substantially at the center of the chip, extending into and accessible from the top surface of the chip;
- a plurality of outlet wells disposed in an outer portion of the chip, extending into and accessible from the top surface of the chip;
- a plurality of multiple segments that extend from the inlet well to the outlet wells, wherein each outlet well is disposed at the end of each of the plurality of multiple segments;
- wherein the multiple segments comprise branched channels;
- wherein the chip is configured to maintain uniform distribution of a liquid and cells from the inlet well to the outlet wells;
- and
- wherein every other outlet well is disposed farther away from the inlet well than an adjacent outlet well.
5 more elements
Dependencies are inferred from the claim text.