Medical devices and methods of making medical devices
AssigneeThe University of Nottingham
InventorRoger Bayston
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Abstract
A medical device material impregnated with a combination of antimicrobial agents, the combination of antimicrobial agents comprising a first antimicrobial agent, the first antimicrobial agent being triclosan and at least a second antimicrobial agent, wherein the combination of antimicrobial agents provides the device material with antimicrobial activity and inhibition of resistant microbial mutations for of the order of, or greater than, 80 days.
Claims22
A medical device material consisting of a polymeric material impregnated with a first antimicrobial agent being triclosan, a second antimicrobial agent being rifampin, and a third antimicrobial agent being clindamycin, wherein the concentration of triclosan in the polymeric material is between 0.1% and 3% w/w in comparison to the weight of the polymeric material, the concentration of the second antimicrobial agent in the polymeric material is 0.05 mg/g in comparison to the weight of the polymeric material, the concentration of the third antimicrobial agent in the polymeric material is 0.16 mg/g in comparison to the weight of the polymeric material and wherein the medical device material provides antimicrobial activity and inhibition of resistant microbial mutations for 80 days or more for both gram-positive and gram-negative bacteria.
A medical device comprising a medical device material consisting of a polymeric material impregnated with a first antimicrobial agent being triclosan, a second antimicrobial agent being rifampin, and a third antimicrobial agent being clindamycin, wherein the concentration of triclosan in the polymeric material is between 0.1% and 3% w/w in comparison to the weight of the polymeric material, the concentration of the second antimicrobial agent in the polymeric material is 0.05 mg/g in comparison to the weight of the polymeric material, the concentration of the third antimicrobial agent in the polymeric material is 0.16 mg/g in comparison to the weight of the polymeric material and wherein the medical device material provides antimicrobial activity and inhibition of resistant microbial mutations for 80 days or more for both gram-positive and gram-negative bacteria.
Dependencies are inferred from the claim text.