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US 10,500,318 B1Granted
Dosing regimens for treating hypoxia-associated tissue damage
AssigneeTemple Therapeutics, Inc.
InventorLynne M. Robertson
Life of this patent
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AssigneeTemple Therapeutics, Inc.
InventorLynne M. Robertson
Estimating the term…
Described herein are methods for the treatment of hypoxia-associated tissue damage in subjects. More particularly, the methods relate to treating hypoxia-associated tissue damage in a subject during a surgical procedure with a therapeutically effective amount of a glutamine source comprising glutamine, a dipeptide comprising glutamine, or a glutamine amino ester conjugate according to particular dosing regimens. Specifically, the methods concern a dosing scheme comprising dosing a subject during a surgical procedure with a glutamine source wherein the first dose is administered to the subject within about 30 minutes following an initial surgical incision made during the surgical procedure, one or more additional doses of the glutamine source is administered at fixed intervals of time after the first dose, and one or more doses is administered just prior to closure of all surgical incisions.
A method of treating or preventing tissue adhesions in a subject that is undergoing a surgical procedure, the method comprising topically administering to the subject during the surgical procedure a therapeutically effective amount of a glutamine source comprising glutamine, a dipeptide comprising glutamine, or a glutamine amino ester conjugate to a tissue that is subject to adhesion formation, wherein a first dose of the glutamine source is administered within about 30 minutes to about 60 minutes after an initial surgical incision during the surgical procedure, one or more additional doses of the glutamine source is administered at fixed intervals of time after the first dose, and one or more doses is administered just prior to closure of the surgical incision.
A method of treating or preventing hypoxia-associated tissue damage in a subject that is undergoing a surgical procedure, the method comprising topically administering to the subject during the surgical procedure a therapeutically effective amount of a glutamine source comprising glutamine, a dipeptide comprising glutamine, or a glutamine amino ester conjugate to a tissue subject to hypoxia-associated tissue damage, wherein a first dose of the glutamine source is administered within about 30 minutes to about 60 minutes after an initial surgical incision during the surgical procedure, one or more additional doses of the glutamine source is administered at fixed intervals of time after the first dose, and one or more doses is administered just prior to closure of the surgical incision.
A method for reducing HIF-1α in hypoxia-associated damaged tissue in a subject that is undergoing a surgical procedure, the method comprising topically administering to the subject during the surgical procedure a therapeutically effective amount of a glutamine source comprising glutamine, a dipeptide comprising glutamine, or a glutamine amino ester conjugate to the damaged tissue, wherein a first dose of the glutamine source is administered within about 30 minutes to about 60 minutes after an initial surgical incision during the surgical procedure, one or more additional doses of the glutamine source is administered at fixed intervals of time after the first dose, and one or more doses is administered just prior to closure of the surgical incision.
Dependencies are inferred from the claim text.