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US 10,500,312 B2Granted
Bioactive porous bone graft compositions with collagen
AssigneeProsidyan, Inc.
InventorsCharanpreet S. Bagga, Steve B. Jung, Hyun W. Bae
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Abstract
Bioactive porous bone graft implants in various forms suitable for use in bone tissue regeneration and/or repair, as well as methods of use are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may be contained in polymer for enhanced clinical results and better handling.
Claims16
A porous, composite bone graft implant, comprising:
- a first component comprising a bioactive glass material in the form of a plurality of porous fibrous clusters, each cluster comprising a matrix of randomly oriented bioactive glass fibers and first bioactive glass granules, and each cluster including a bioactive glass shell at least partially encasing each cluster, wherein the size of each cluster is about 0.75 mm to about 4 mm;
- a second component comprising a plurality of second bioactive glass granules, wherein the size of each second bioactive glass granule is about 50 μm to about 450 μm;
- and
- a third component comprising a collagen material for incorporation with the first and second components;
- each of the components having a different resorption rate than the other component;
- wherein the composite implant comprises a pore size distribution including pores characterized by pore diameters ranging from about 100 nanometer to about 1 millimeter, and wherein the composite implant is pliable.
3 more elements
Dependencies are inferred from the claim text.