US 10,500,305 B2 · Device and method for a nanofiber wrap to minimize inflamation and scarring

Abstract

The present invention is directed to a device and method for a nanofiber wrap to minimize inflation and scarring of nerve tissue and maximize the nutrient transport. More particularly, the present invention is directed to a novel semi-permeable nanofiber construct prepared from biocompatible materials. The nanofiber construct is applied around a nerve repair site following end-to-end anastomosis. The nanofiber construct is porous and composed of randomly oriented nanofibers prepare using an electrospinning method. The nanofiber construct has a wall that is approximately 50-100 μm thick with pores smaller than 25 μm. The nanofiber construct prevents inflammatory cells from migrating into the nerve coaption site, while still permitting the diffusion of growth factors and essential nutrients. The nanofiber construct allows for enhanced neuroregeneration and optimal function outcomes.

Claims9

Dependent claims

A device for promoting healing at a connection site between tubular biologic structures comprising:

a porous, semipermeable construct of nanofibers;
wherein the nanofibers are spun from a biocompatible material in a sheet configured and sized for wrapping around the connection site tubular biologic structures;
and
wherein the sheet is configured to have a pore size to entrap inflammatory cells and prevent infiltration of inflammatory cells to the connection site, while permitting nutrient supply.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

15/128,257Filed 9 Apr 2015 · us provisional application

Priority

10 Apr 2014

Published

US 2017/0095591 A16 Apr 2017

Granted

10 Dec 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

A61L 27/18
Macromolecular materials: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/26
Macromolecular materials: mixtures of macromolecular compounds
A61L 27/50
Materials for grafts or prostheses or for coating grafts or prostheses: materials characterised by their function or physical properties , e.g.…
A61L 27/56
Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface…:…

Device and method for a nanofiber wrap to minimize inflamation and scarring

Life of this patent

Device and method for a nanofiber wrap to minimize inflamation and scarring

Life of this patent

Abstract

Claims9