US 10,500,304 B2Granted

Films and methods of manufacture

AssigneeDePuy Synthes Products, Inc.

InventorsDavid A. Armbruster, James Dwyer, Jeffrey Chomyn, Sean H. Kerr

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Abstract

Embodiments of the present disclosure are directed to perforated polymer films and methods of making the same. In some embodiments, the films are for use with implantable medical devices. In one embodiment there is a flexible body including a polymer film having a first surface and an opposing second surface, the film having a plurality of apertures extending from the first surface to the second surface and a plurality of raised lips protruding from the first surface such that each of the plurality of apertures is surrounded by a one of the plurality of raised lips. In one embodiment, the film comprises a single layer, and in another embodiment, the film can comprise a plurality of layers. In certain embodiments, the film can comprise an adhesive layer. In another embodiment, one or more of the layers may be a drug containing layer and/or a rate controlling layer for drug release.

Claims15

Dependent claims

A method of forming a biocompatible and implantable multi-layer film for drug delivery comprising:

placing a first polymer solution comprising a biodegradable polymer into a mold having a plurality of protrusions extending from a bottom of the mold;
urging the first polymer solution around each of the plurality of protrusions such that a meniscus of polymer solution is formed around the plurality of protrusions;
placing one or more additional polymer solutions into the mold, the one or more additional polymer solutions comprising a biodegradable polymer, wherein at least one of the first polymer solution or the one or more additional polymer solutions further comprises a drug;
and,
solidifying the first polymer solution and the one or more additional polymer solutions so as to form a biocompatible and biodegradable multi-layer film configured for implantation, wherein the drug is incorporated within film;
wherein the step of solidifying comprises solidifying the meniscus of polymer solution so as form a plurality of raised lips around the plurality of protrusions;
wherein a plurality of apertures is formed in the multi-layer film from the protrusions, the plurality of apertures extending completely through the multi-layer film from a first surface to a second surface and wherein each of plurality of the raised lips surrounds a respective aperture of the plurality of apertures.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/725,586Filed 5 Oct 2017 · division
Priority: 21 Jun 2013
Published: US 2018/0028714 A11 Feb 2018
Granted: 10 Dec 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification21 codes

A61L 24/0015
Use of materials characterised by their function or physical properties: medicaments; Biocides
A61B 17/80
Internal fixation devices , including fasteners and spinal fixators, even if a part thereof projects from the skin: cortical plates , i.e. bone…
A61B 17/8057
Immobilised relative to screws by interlocking form of the heads and plate holes, e.g. conical or threaded: the interlocking form comprising a thread
A61B 17/8085
Cortical plates , i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates:…

Family

Application61/837,716Us provisional application · filed 21 Jun 2013
PCT/US2014/041662Parent of this division · filed 10 Jun 2014
US 2018/0028714 A1Pre-grant publication · published 1 Feb 2018
Application14/899,570Parent of this division
US 2016/0144067 A1Published application
US 10,500,304 B2This patent

From the US filing history. Foreign family members aren’t listed.

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