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US 10,500,303 B2Granted
Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
AssigneeTepha, Inc.
InventorsSaid Rizk, Simon F. Williams
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AssigneeTepha, Inc.
InventorsSaid Rizk, Simon F. Williams
Estimating the term…
Absorbable monofilament fibers and self-retaining sutures with high tensile strengths have been developed. The straight pull tensile strengths of the absorbable self-retaining sutures closely approximate, equal or exceed the average minimum knot-pull tensile standards set by the United States Pharmacopeia (USP). These higher strength absorbable self-retaining sutures can therefore be used either without needing to oversize the suture for a given procedure, or by oversizing the self-retaining suture by no more than 0.1 mm in diameter. In one embodiment, the absorbable self-retaining sutures are made from poly-4-hydroxybutyrate or copolymers thereof. Methods for producing absorbable self-retaining sutures that have high tensile strengths and pronounced sheath-core structures wherein the sheath is harder than the core are also provided. The self-retaining sutures may be made by spinning and orienting a monofilament fiber of poly-4-hydroxybutyrate or copolymer thereof and inserting retainers in monofilament fibers.
An absorbable self-retaining suture made from a monofilament fiber, wherein the monofilament fiber comprises a sheath-core structure, wherein the core structure comprises the same polymer as the sheath, and the core and sheath are oriented, wherein the fiber has been stretched at least 6 times its original length without subsequent relaxation of the fiber, wherein the sheath and the core have indentation hardness, and the indentation hardness of the sheath is higher than the indentation hardness of the core, and wherein the self-retaining suture minimum straight pull tensile strength is selected from the group consisting of
A monofilament fiber of poly-4-hydroxybutyrate or copolymer thereof comprising a sheath-core structure, wherein the monofilament has a Young's modulus greater than 860 MPa, wherein (a) the core structure and the sheath structure comprise poly-4-hydroxybutyrate homopolymer, or (b) the core structure and the sheath structure comprise or a copolymer of poly-4-hydroxybutyrate, wherein the fiber has been stretched at least 6 times its original length without subsequent relaxation of the fiber, wherein the sheath and the core have indentation hardness, and the indentation hardness of the sheath is higher than the indentation hardness of the core.
Dependencies are inferred from the claim text.