Back to results
US 10,500,292 B2Granted
PSMA-binding agents and uses thereof
AssigneeThe Johns Hopkins University
InventorsMartin G. Pomper, Ronnie Charles Mease, Ying Chen
Life of this patent
Estimating the term…
Abstract
Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.
Claims4
A method of preparing a compound of the formula:
- the method comprising contacting a compound of the formula:
- with TFA, wherein each instance of PMB is p-methoxybenzyl.
A method of preparing a compound of the formula:
- the method comprising contacting a compound of the formula:
- with K18F and K222.
Dependencies are inferred from the claim text.