US 10,500,291 B2 · Mechanisms involved in the formation of biocompatible lipid polymeric patchy particles

Abstract

The invention relates to lipid polymeric patchy particles formed by nanoprecipitation and emulsification processes, utilizing a polymer blend including the polymer, solvent and lipid-PEGylated functional groups. More particularly, the invention relates to synthesizing particles having different or pre-selected morphologies (internal and external) and physicochemical properties. It has been found that the shear stress experienced by the polymer blend during emulsification can impart certain external and internal morphology and physicochemical properties to the resulting particles. Further, the one or more patches of the particles can be functionalized, such as, with gold nanoparticles, for use of the particles, in particular, in photoacoustic and ultrasound imaging.

Claims13

Dependent claims

A lipid polymeric patchy particle comprising:

a hollow core having an inner lining and an outer surface surrounding the inner lining,
one or more shells surrounding the outer surface,
a single patch formed on the outermost shell, and
a first lipid functional group having a first end and a second end, wherein the first end is bound to the outer surface, thereby forming a first shell, and wherein the second end has a first functional group,
wherein the inner lining comprises a semi-conductor polymer and
wherein the outer surface comprises a hydrophobic polymer.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/055,142Filed 26 Feb 2016 · us provisional application

Priority

26 Feb 2015

Published

US 2016/0250357 A11 Sep 2016

Granted

10 Dec 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification3 codes

A61K 49/225
Characterised by a special physical form, e.g. emulsions, liposomes: microparticles, microcapsules
A61K 49/223
Characterised by a special physical form, e.g. emulsions, liposomes: microbubbles, hollow microspheres, free gas bubbles, gas microspheres
A61K
Medicines and medical preparations

Mechanisms involved in the formation of biocompatible lipid polymeric patchy particles

Life of this patent

Mechanisms involved in the formation of biocompatible lipid polymeric patchy particles

Life of this patent

Abstract

Claims13