Vaccine composition capable of inducing memory antibody response from single point immunization
AssigneeNational Institute of Immunology
InventorsAnish Chakkumkal, Amulya Kumar Panda
Life of this patent
Estimating the term…
Abstract
The present investigation relates to entrapment of carbohydrate antigen such as Vi polysaccharide of Salmonella typhi in poly (DL) lactide (PDLLA) and polylactide-co-glycolide (PLGA) polymer particles. The formulated product not only elicits primary antibody titers from single dose application but also evokes memory antibody titer against the T independent antigen.
Claims8
A vaccine composition consisting of a carbohydrate antigen Vi polysaccharide of Salmonella typhi entrapped in a polymer particle wherein said polymer particle is selected from poly (DL) lactide (PDLLA) and polylactide-co-glycolide (PLGA), said composition capable of inducing memory antibody response from a single immunization, by multivalent display of polysaccharide antigens on polymeric particles wherein the polymer particles are of a size distribution of 2-8 μm, the composition free of adjuvant.
Dependencies are inferred from the claim text.