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US 10,500,281 B2Granted
Injectable long-acting local anesthetic semi-solid formulations and its compositions
AssigneeMira Pharma Corporation
InventorsHui Rong Shen, Na Gan
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Abstract
What is disclosed is a semi-solid controlled release pharmaceutical composition containing biocompatible and bioerodible semi-solid lipid matrix incorporating local anesthetics agents to form a semi-solid solution, a method of using the pharmaceutical composition to treat, and a method of making the pharmaceutical composition.
Claims5
A pharmaceutical composition consisting of
- 5-14% bupivacaine,
- 63-76% a mixture of ricinoleic acid partial glycerides (S701), and
- 17-27% a mixture of C12-C18 fatty acids (G39/01);
- wherein the pharmaceutical composition consists of a biocompatible, bioerodible, homogeneous, semi-solid gel;
- and wherein the semi-solid gel consists of a soft paste with a viscosity of 408-1095 cPs at 30° C., and forms a depot in an aqueous buffer that releases less than 80% of the bupivacaine in five days when measured in vitro at 37° C.
2 more elements
Dependencies are inferred from the claim text.