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US 10,500,279 B2Granted
Low toxicity topical active agent delivery system
OwnerJohn E. Kuleszainventor
Life of this patent
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Abstract
An active agent delivery composition is provided that allows topical delivery of active agents including vitamin A and its derivatives. A polyhalogenic vehicle serves as a coupler for an active agent and a silicone carrier so as to allow solubilization of active agents not normally miscible in silicones and providing a moisture maintaining composition.
Claims19
An active agent topical delivery composition comprising:
- an active agent present at a concentration between 0.001 to 0.5 weight percent, said active agent selected from the group consisting of vitamin A or its derivatives, salicylic acid, and benzoyl peroxide;
- a volatile linear organopolysiloxane carrier with 2 to 6 silicon atoms present at 10 percent to 75 percent by weight;
- a vehicle selected from the group consisting of methoxynonafluorobutane, ethoxynonafluorobutane, or a combination thereof, said vehicle present at from 5 percent to 40 percent by weight;
- and
- an alcohol at less than 5% by weight;
- said composition free of water and ethanol,
- wherein said active agent is insoluble at said concentration of active agent if in a fluid consisting of said active agent and said carrier or in a fluid consisting of said active agent and said vehicle, and wherein and the active agent fully soluble in the carrier and the vehicle combined at said concentration;
- and
- wherein the composition is clear liquid solution of said active agent at room temperature.
6 more elements
A skin care composition comprising:
- a vitamin A or vitamin A derivative at a concentration between 0.01 to 0.5 weight percent;
- a volatile linear organopolysiloxane carrier of 2 to 6 silicon atoms present at 10 percent to 75 percent by weight;
- a vehicle selected from the group consisting of methoxynonafluorobutane, ethoxynonafluorobutane, or a combination thereof, said vehicle having a boiling point less than 78 degrees Celsius, said vehicle present at from 5 percent to 40 percent by weight;
- and
- an alcohol at 0-5 percent by weight;
- wherein said active agent is insoluble at said concentration if in a fluid consisting of said active agent and said carrier or in a fluid consisting of said active agent and said vehicle, and wherein and the active agent fully soluble in the carrier and the vehicle combined at said concentration;
- said composition free of water and ethanol, and
- wherein the composition is clear liquid solution of said active agent at room temperature.
5 more elements
Dependencies are inferred from the claim text.