Combination tumor treatment with drug-loaded, bispecific ligand-targeted minicells and interferon-gamma

A composition comprising:

• (a) a plurality of intact bacterial minicells or intact killed bacterial cells, each of which(i) encompasses an anti-neoplastic agent selected from the group consisting of a radionucleotide;
• a chemotherapy drugs;
• a functional nucleic acid selected from the group consisting of siRNA, miRNA, shRNA, lincRNA, antisense RNA, and ribozyme;
• and a polynucleotide that transcribes a functional nucleic acid selected from the group consisting of siRNA, miRNA, shRNA, lincRNA, antisense RNA, and ribozyme and (ii) carries a ligand on the surface of the intact minicells or bacterial cells, wherein the ligand has specificity to a non-phagocytic mammalian cell surface receptor, wherein the non-phagocytic mammalian cell surface receptor is a tumor cell antigen;
• and
• (b) interferon-gamma (IFN-gamma).