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AssigneeCytoDyn Inc.
InventorsWilliam C. Olson, Paul J. Maddon, Daniel C. Pevear, Robert J. Israel, Jose D. Murga
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This invention provides a method of reducing viral load in an HIV-1-infected human subject which comprises administering to the subject an effective HIV-1 viral load reducing dose of a CCR5 receptor antagonist, such as a humanized antibody designated PRO 140 or an anti-CCR5 receptor monoclonal antibody, wherein the viral load reducing dose achieves an average maximum decrease of viral load in the subject of at least 1.83 log10 to 2.5 log10 at about ten days following administration of the CCR5 receptor antagonist and wherein the viral load reducing dose further achieves a mean viral load reduction of 1.7 log10 at about nine days following administration of the CCR5 receptor antagonist.
A CCR5 receptor antagonist formulation consisting of a therapeutically effective single subcutaneous dose of a humanized monoclonal antibody designated PRO 140, or a fragment thereof, in an amount 5 mg/kg of body weight for an HIV-infected subject, wherein said formulation results in suppression of HIV-1 viral replication.
A therapeutic composition comprising a therapeutically effective single subcutaneous or intravenous dose of a CCR5 receptor antagonist in an amount of 5 mg/kg for an HIV-infected subject that results in suppression of HIV-1 viral replication, wherein the CCR5 receptor antagonist is a humanized monoclonal antibody designated PRO 140 or a fragment thereof, or a conjugate of said CCR5 receptor antagonist.
A pharmaceutical composition comprising a CCR5 receptor antagonist subcutaneous formulation consisting of a therapeutically effective single subcutaneous dose of a humanized monoclonal antibody (mAb) designated PRO 140, or a fragment thereof, in an amount of 5 mg/kg of body weight for an HIV-1-infected subject, wherein said composition results in suppression of HIV-1 viral replication.
Dependencies are inferred from the claim text.