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US 10,500,264 B2Granted
Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsStephen S. Whitehead, Brian R. Murphy, Kathryn A. Hanley, Joseph E. Blaney, Ching-Juh Lai
Life of this patent
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Abstract
A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.
Claims13
A dengue virus comprising a U to C mutation at nucleotide 10634 of the 3′ untranslated region, wherein the numbering is based upon the prototypic isolate DEN4 Dominica 1981 and wherein the virus has a phenotype comprising temperature sensitivity in Vero cells or human liver cell line HuH-7 and/or attenuation in mice.
Dependencies are inferred from the claim text.