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AssigneeThe United States of America as represented by the Secretary of the Navy
InventorsPatricia Guerry, Mario Artur Monteiro, Yuening Jiao, Brittany Michele Pequegnat
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The invention relates to immunogenic synthetic constructs capable of inducing an immune response against Campylobacter jejuni (C. jejuni) in a subject comprising one or more monosaccharides comprising one or more MeOPN moieties. Specifically, the invention relates to immunogenic synthetic constructs capable of inducing an immune response against C. jejuni in a subject comprising one or more MeOPN-6-Gal monosaccharides, one or more MeOPN-4-Gal monosaccharides, and/or one or more MeOPN-2-Gal monosaccharides. The invention also relates to compositions comprising the immunogenic synthetic constructs, and methods of inducing an immune response against C. jejuni in a subject comprising administering the immunogenic synthetic constructs, and/or compositions comprising the immunogenic synthetic constructs, to the subject. Methods of treating, preventing, or ameliorating a C. jejuni bacterial infection in a subject comprising administering to the subject one or more doses of immunoglobulins directed to one or more of the MeOPN moieties are also contemplated.
An immunogenic synthetic construct capable of inducing an immune response against Campylobacter jejuni (C. jejuni) in a subject, wherein said immunogenic synthetic construct comprises one or more monosaccharides comprising one or more O-methyl phosphoramidate (MeOPN) moieties, wherein said one or more monosaccharides comprising one or more MeOPN moieties is MeOPN-4-Gal.
A method of treating or ameliorating a C. jejuni bacterial infection in a subject in need thereof comprising administering to the subject one or more doses of immunoglobulins, wherein said immunoglobulins recognize MeOPN-4-Gal and optionally recognize one or more additional MeOPN moieties, in the capsule of said C. jejuni bacteria.
Dependencies are inferred from the claim text.