Small molecule cellular reprogramming to generate neuronal cells
AssigneeThe J. David Gladstone Ins., a testamentary trust established under the Will of J. David Gladstone
InventorsChangsheng Lin, Sheng Ding
Life of this patent
Estimating the term…
Abstract
Compositions and methods are described herein for chemically inducing cells to change their differentiation state and become neuronal cells.
Claims13
A method of generating a neuronal cell comprising incubating a selected population of non-pluripotent, non-neuronal cells with the composition comprising CHIR99021, an ALK5 and ALK4 inhibitor, a histone deacetylase inhibitor, and a p300 activator, to thereby generate neuronal cells, neuronal progenitor cells, or a combination thereof without de-differentiating the population of non-pluripotent, non-neuronal cells into a population of cells exhibiting pluripotent stem cell characteristics.
Dependencies are inferred from the claim text.