Mutual prodrug comprising short chain fatty acids and zebularine or 1'-cyano-cytarabine for cancer treatment
AssigneeKainos Medicine, Inc.
InventorsSunmi Shin, Hyangmi Kim, Su-Sung Oh
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Abstract
The present invention provides mutual prodrugs comprising anti-cancer nucleosides and short chain fatty acids; methods for production of the mutual prodrugs; methods of treatment comprising administration of the mutual prodrugs; and pharmaceutical compositions comprising the mutual prodrugs. Further, the mutual prodrugs of the present invention can be used as therapeutic agents for the treatment of cancer diseases and conditions.
Claims6
A compound consisting of a nucleoside of Formula (I) or (II) covalently linked to one or more short chain fatty acids (SCFAs) or a derivative thereof, wherein the SCFAs are selected from the group consisting of butyric acid and isobutyric acid, and the SCFAs are linked at 5′ position, or 2′, 3′, and 5′ positions of the nucleoside of formula (I) or (II):
Dependencies are inferred from the claim text.