Compositions and methods relating to treatment of infection
AssigneeWayne State University
InventorLinda D. Hazlett
Life of this patent
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Abstract
Microbial keratitis is a sight threatening disorder and infections result in ocular pain, stromal destruction, corneal thinning and/or perforation, leading to vision loss, if untreated and the need for transplantation. Methods of treating bacterial infection of the cornea prophylactically or therapeutically in a subject, are provided according to aspects of the present invention which include administering an effective dose of glycyrrhizin, or a pharmaceutically acceptable salt, hydrate, solvate, ester, amide, isomer or derivative thereof characterized by anti-bacterial activity, to the subject.
Claims9
A method of treating Pseudomonas aeruginosa infection of the cornea therapeutically in a subject, comprising:
- administering a composition comprising an effective dose of glycyrrhizin, or a pharmaceutically acceptable salt, hydrate, solvate, amide, or isomer thereof to the subject, wherein no additional therapeutic agent is included in the composition, thereby reducing bacterial load in the cornea and thereby treating Pseudomonas aeruginosa infection of the cornea therapeutically in the subject.
Dependencies are inferred from the claim text.