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US 10,500,208 B2Granted
Emulsion formulations of aprepitant
AssigneeHeron Therapeutics, Inc.
InventorsThomas B. Ottoboni, Han Han
Life of this patent
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Abstract
Disclosed herein are novel pharmaceutical formulations of aprepitant suitable for parenteral administration including intravenous administration. Also included are formulations including both aprepitant and dexamethasone sodium phosphate. The pharmaceutical formulations are stable oil-in-water emulsions for non-oral treatment of emesis and are particularly useful for treatment of subjects undergoing highly emetogenic cancer chemotherapy.
Claims17
An injectable emulsion comprising:
- aprepitant;
- 11 wt/wt % to 15 wt/wt % of an emulsifier;
- an oil;
- a co-emulsifier which is an alcohol;
- a tonicity modifier;
- a pH modifier;
- and
- water;
- wherein the pH of the emulsion ranges from about 7.5 to 9.0,
- wherein the emulsion is physically stable.
7 more elements
Dependencies are inferred from the claim text.