Drug delivery systems and methods for treatment of bladder dysfunction or disorder using trospium
AssigneeTARIS Biomedical LLC
InventorDennis Giesing
Life of this patent
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Abstract
Methods, devices, and medicaments that include trospium are provided for use in the treatment of bladder dysfunction by locally administering the trospium into the bladder to achieve a sustained concentration of trospium in urine in the bladder sufficient to produce a therapeutic concentration of trospium in bladder tissue. The drug may be delivered into the bladder from an intravesical drug delivery device inserted into the bladder, wherein the device continuously releases the drug into the urine in the bladder over an extended period of hours or days.
Claims7
A method of administering trospium to a patient in need of treatment of overactive bladder, the method comprising:
- locally administering trospium into the bladder of a patient to achieve a sustained concentration of trospium in urine in the bladder sufficient to produce a therapeutic concentration of trospium in bladder tissue over a treatment period from 1 week to 6 months,
- wherein the locally administering into the patient's bladder is from an intravesical drug delivery device which continuously releases the trospium into the urine in the bladder at a mean average amount of from 0.15 mg/day to about 15 mg/day over the treatment period,
- wherein the sustained concentration of trospium in urine in the bladder is from 0.05 μg/ml to 100 μg/ml continuously over the treatment period.
Dependencies are inferred from the claim text.