Antibacterial compounds
AssigneeWockhardt Limited
InventorsVijaykumar Jagdishwar Patil, Ravikumar Tadiparthi, Piyush Ambalal Patel, Rajib Bhuniya, Sachin Bhagwat, Swapna Shripad Takalkar, Rajesh Chavan, Anusuya Patel, Vipul Rane, Mahesh Vithalbhai Patel
Life of this patent
Estimating the term…
Abstract
Compounds of Formula (I), or a stereoisomer or a pharmaceutically acceptable salt thereof, their preparation, pharmaceutical compositions comprising such compounds and their use in treating and/or preventing bacterial infections are disclosed.
Claims26
A compound of Formula (I),
- or a stereoisomer or a pharmaceutically acceptable salt thereof.
A compound which is (2S, 5R)-N-{[(2S, 4S)-4-fluoropyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide, or a stereoisomer or a pharmaceutically acceptable salt thereof.
A process for preparation of a compound of Formula (Ia):
- comprising:
- (a) converting a compound of Formula (IIa) into a compound of Formula (IIIa) in the presence of a fluorinating agent:
- (b) converting a compound of Formula (IIIa) into a compound of Formula (IVa):
- (c) converting a compound of Formula (IVa) into a compound of Formula (Va):
- (d) converting a compound of Formula (Va) into a compound of Formula (VIa):
- (e) reacting a compound of Formula (VIa) with a compound of Formula (VII) to obtain a compound of Formula (VIIIa):
- (f) converting a compound of Formula (VIIIa) into a compound of Formula (IXa):
- (g) converting a compound of Formula (IXa) into a compound of Formula (Xa):
- and
- (h) converting a compound of Formula (Xa) into the compound of Formula (Ia).
Dependencies are inferred from the claim text.