Combination therapy of HSP90 inhibitors with platinum-containing agents

A method of treating cancer, wherein the cancer is breast cancer, gastric cancer, colorectal cancer, pancreatic cancer, ocular melanoma, prostate cancer, gastrointestinal stromal tumors (GIST), advanced esophagogastric cancer, melanoma, hepatocellular cancer, solid tumor, liver cancer, head and neck cancer, small cell lung cancer, non-small cell lung cancer, bladder cancer, testicular tumor, ovarian cancer, lymphoma, leukemia, multiple myeloma, or colon cancer, comprising administering to the subject (a) an effective amount of an Hsp90 inhibitor, wherein the Hsp90 inhibitor is selected from the group consisting of 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(1-methyl-indol-5-yl)-5-hydroxy-[1,2,4] triazole or a tautomer or a pharmaceutically acceptable salt thereof and 5-hydroxy-4-(5-hydroxy-4-(1-methyl-1H-indol-5-yl)-4H-1,2,4-triazol-3-yl)-2-isopropylphenyl dihydrogen phosphate, or a tautomer, or a pharmaceutically acceptable salt thereof, and (b) a platinum-containing anti-cancer agent, wherein the platinum-containing anticancer agent is selected from the group consisting of cisplatin, carboplatin, and oxaliplatin.