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US 10,500,191 B2Granted
Compositions and methods of use of antibacterial drug combinations
AssigneeWashington University
InventorsGautam Dantas, Patrick Gonzales, Kevin Forsberg, Mitchell Pesesky, Mayland Chang, Shahriar Mobashery
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Abstract
The present disclosure encompasses antibacterial compositions and methods of treating bacterial infections caused by resistant bacteria.
Claims8
A composition useful for the treatment of an infection caused by a methicillin-resistant Staphylococcus aureus (MRSA), wherein the resistance is due to a penicillin-binding protein 2a (PBP2a)-driven mechanism, the composition comprising:
- i) at least one carbapenem or another β-lactam capable of binding the allosteric site of PBP2a;
- ii) at least one β-lactamase inhibitor;
- and
- iii) at least one β-lactam that binds the open configuration of the active site of PBP2a;
- wherein the composition is selected from the group consisting of
- a) meropenem/piperacillin/tazobactam (ME/PI/TZ);
- b) cefepime/piperacillin/tazobactam (CP/PI/TZ);
- c) aztreonam/piperacillin/tazobactam (AZ/PI/TZ);
- d) meropenem/amoxicillin/tazobactam (ME/AX/TZ);
- e) meropenem/amoxicillin/clavulanate (ME/AX/CV);
- and
- f) imipenem/piperacillin/clavulanate (IM/PI/CV).
9 more elements
Dependencies are inferred from the claim text.