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US 10,500,185 B2Granted
Stabilized cabazitaxel formulations
AssigneeCipla Limited
InventorsGeena Malhotra, Sarabjit Singh, Ravichandra Bhadravathi Vedamurthy, Anirban Mallik Thakur, Dhiraj Abhyankar
Life of this patent
Estimating the term…
Abstract
Disclosed herein are improved formulations for the cabazitaxel. The formulations exhibit increased storage stability relative to other formulations, and are simpler for health care providers to prepare and administer to patients.
Claims18
A sterilized pharmaceutical composition, comprising a compound having the formula:
- or a pharmaceutically acceptable salt thereof, in a concentration of about 5 mg/ml to about 200 mg/ml, and at least one solubilizer wherein:
- a) the solubilizer comprises a compound of the formula
- wherein x is an integer from 1-20;
- y1 is an integer from 2-20;
- z1 is an integer from 1-15;
- and
- Z1 is selected from hydrogen or the group OR, in which R is selected from hydrogen and a group having the formula:
- wherein y2 is an integer from 2-20;
- z2 is an integer from 1-15;
- and Z2 is selected from hydrogen or hydroxyl, or
- b) the solubilizer comprises compound of the formula
- wherein x2 is an integer from 1-20;
- wherein y3 is an integer from 1-20;
- z3 is an integer from 0-15;
- Z3 is selected from hydroxyl and hydrogen, and Z4 is selected from hydroxyl and the group having the formula:
- wherein y4 is an integer from 1-20;
- z4 is an integer from 0-15;
- and Z5 is selected from hydrogen or hydroxyl,
- wherein the composition is a solution and does not include Cremophor EL.
16 more elements
Dependencies are inferred from the claim text.