Nanoparticle-based combinatorial therapy

A nano-particle based composition for a combinational therapy for treatment of breast cancer comprising:

• doxorubicin physically loaded on core-shell silver polymeric nanoparticles with a ratio of 3.3-5.5 parts doxorubicin to 1 part silver to 2-10 parts polymer,
• wherein the core-shell silver polymeric nanoparticles comprises the silver in the core and the shell comprises the polymer,
• wherein the polymer is poly-vinyl alcohol (PVA), poly-ethylene glycol (PEG), or poly-vinyl pyrrolidone (PVP),
• wherein the doxorubicin is present in the silver core,
• wherein the silver core is stabilized by sodium citrate,
• wherein the concentration of the doxorubicin in the composition is less or equal to 0.2 μg/ml, and
• wherein the core-shell silver polymeric nanoparticles act as nanocarriers and anti-cancer agents for the treatment of breast cancer.