US 10,500,158 B2 · Cationic lipid

Abstract

The present invention provides a cationic lipid represented by the formula (I) wherein R1 and R2 each represents alkyl having 8 to 24 carbon atoms or the like; R3 represents a hydrogen atom, alkyl having 1 to 3 carbon atoms, the formula (A) wherein R4 and R5 each represents a hydrogen atom or the like, and n3 represents an integer from 2 to 6, or the formula (B) wherein R6 and R7 each represents a hydrogen atom or the like, and n4 represents an integer from 1 to 6; n1 represents an integer from 0 to 4; and n2 represents an integer from 1 to 4, provided that the case where n1 is 0 and n2 is 1 is excluded, and a composition which contains the cationic lipid and a nucleic acid, or the like.

Claims13

Dependent claims

A cationic lipid of the formula (I″):

wherein R1′ and R2′ are, the same or different, linear, alkenyl, having 12 to 24 carbon atoms;
R3′ is alkyl having 1 to 3 carbon atoms.

Dependencies are inferred from the claim text.

Facts

Application

15/322,271Filed 30 Jun 2015

Priority

JP 2014-13391330 Jun 2014

Published

US 2017/0224619 A110 Aug 2017

Granted

10 Dec 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification21 codes

A61K 9/1272
Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers: comprising non-phosphatidyl surfactants as…
A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61K 31/7105
Compounds having three or more nucleosides or nucleotides: natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine,…
A61K 31/713
Compounds having three or more nucleosides or nucleotides: double-stranded nucleic acids or oligonucleotides

Cationic lipid

Life of this patent

Cationic lipid

Life of this patent

Abstract

Claims13