Multi-compartmental macrophage delivery
AssigneeNortheastern University
InventorsMansoor M. Amiji, Mayur Kalariya, Shardool Jain, Husain Attarwala
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Abstract
Disclosed are multi-compartmental nanoparticulate systems for imaging as well as the diagnosis, monitoring, and treatment of inflammation and/or disease. These multicompartmental nanoparticulate systems can be used to target specific cells or cellular structures. Furthermore, these systems are capable of simultaneous delivery of hydrophilic and lipophilic compositions. Finally, these systems also allow for temporal control of drug delivery.
Claims29
A method of imaging a macrophage with a multicompartment delivery system, the method comprising:
- (a) administering an effective amount of the multicompartment delivery system to a subject, the multicompartment delivery system comprising one or more inner aqueous compartments encapsulated within an outer hydrophobic compartment, the outer hydrophobic compartment encapsulated in an exterior aqueous compartment;
- wherein the one or more inner aqueous compartments comprise a nanoparticle consisting of a polymeric matrix, at least one imaging agent, and optionally at least one therapeutic agent;
- and wherein the outer hydrophobic compartment is 0.5 to 20 microns in size and comprises an oil;
- (b) allowing the multicompartment delivery system to deliver the imaging agent to a macrophage;
- and
- (c) detecting the imaging agent in the subject.
A method of treating a disease with a multicompartment delivery system for targeting a macrophage, the method comprising:
- (a) administering an effective amount of the multicompartment delivery system to a subject, the multicompartment delivery system comprising one or more inner aqueous compartments encapsulated within an outer hydrophobic compartment, the outer hydrophobic compartment encapsulated in an exterior aqueous compartment;
- wherein the one or more inner aqueous compartments comprise a nanoparticle consisting of a polymeric matrix, at least one therapeutic agent, and optionally at least one imaging agent;
- and wherein the outer hydrophobic compartment is 0.5 to 20 microns in size and comprises an oil;
- and
- b) allowing the multicompartment delivery system to deliver the therapeutic agent to a macrophage.
Dependencies are inferred from the claim text.