Loading patent…
AssigneeNMI Naturwissenschaftliches und Medizinisches Institut an der Universitaet Tuebingen
InventorsJuergen Mollenhauer, Karin Benz, Barbara Platz, Helmut Wurst, Reinout Stoop
Estimating the term…
The invention relates to an injectable biocompatible composition based on a polymeric support as well as to a method for producing it, which composition which comprises at least one hydrophilic polymer, wherein the polymer is polymerizable in situ to form a gel, and wherein the hydrophilic polymer is crosslinkable serum albumin or crosslinkable serum protein. The composition can be used in the restoration, the reconstruction, and/or the replacement of tissues and/or organs, or as a drug release implant in mammals. The composition is particularly suitable for treating cartilage disorders of a diseased or injured articular site in a mammal.
Method for treating cartilage disorders of a diseased or injured articular site in a mammal, said method comprising the steps of providing an injectable biocompatible composition based on a polymeric support which polymeric support comprises a hydrophilic polymer, wherein the hydrophilic polymer is polymerizable in situ to form a gel, wherein the hydrophilic polymer is serum albumin and wherein the serum albumin is functionalized by maleimide groups, wherein the serum albumin is cross-linked in situ via the groups via a thiol reaction, and injecting the composition into the articular site to be treated.
Method for treating cartilage disorders of a diseased or injured articular site in a mammal, said method comprising the steps of providing an injectable biocompatible composition based on a polymeric support which polymeric support comprises a hydrophilic polymer, wherein the hydrophilic polymer is polymerizable in situ to form a gel, wherein the hydrophilic polymer is serum albumin or serum protein and wherein the serum albumin or serum protein is functionalized by maleimide, wherein the serum albumin or serum protein is cross-linked in situ via the groups via a thiol reaction, and wherein the composition further comprises a SH group-containing crosslinker, and injecting the composition into the articular site to be treated.
Dependencies are inferred from the claim text.