Polyphenols/PEG based hydrogel system for a dental varnish
AssigneeDENTSPLY SIRONA Inc.
InventorsAmit Jha, Thomas C. Simonton
Life of this patent
Estimating the term…
Abstract
Described herein are dental treatment compositions, more particularly, a dental varnish composition useful in effective fluoridation, enhancement of remineralization the tooth enamel, and hypersensitivity through occlusion of dentine tubule. The dental varnish composition includes a hydrogel system and at least one fluoride source, wherein the dental varnish is water soluble. The hydrogel system includes at least one polyphenol having at least one phenol group, at least one polymer, and a metal ion. Described herein are also methods of making such dental varnish composition.
Claims32
A hydrogel system for use in a dental varnish, said hydrogel system comprising:
- (a) at least one compound having at least one phenol group;
- (b) at least one polymer comprising a functional group capable of forming a hydrogen bond with said at least one compound having at least one phenol group;
- and
- (c) a metal ion, wherein the at least one compound having at least one phenol group includes both tannic acid and gallic acid;
- and
- wherein the hydrogel system is capable of forming a crosslinked film while simultaneously adhering to an enamel surface of a tooth.
A dental varnish composition comprising a hydrogel system and at least one fluoride source;
- wherein the hydrogel system comprises at least one compound having at least one phenol group;
- at least one polymer comprising a functional group capable of forming a hydrogen bond with said at least one compound having at least one phenol group, and a metal ion source, wherein the at least one compound having at least one phenol group includes both tannic acid and gallic acid;
- and, wherein the dental varnish is water soluble.
A method of preparing a dental varnish comprising:
- (a) dissolving at least one compound having at least one phenol in a solvent to form a phenolic solution;
- (b) adding an antioxidant and metal ion source to the phenolic solution;
- (c) mixing the phenolic solution with a polymer solution to prepare a hydrogel system;
- (d) removing the solvent from the hydrogel system;
- and
- (e) mixing the hydrogel system with a fluoride source to form the dental varnish, wherein the at least one compound having at least one phenol group includes both tannic acid and gallic acid.
Dependencies are inferred from the claim text.