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US 10,499,854 B2Granted
Eliminating acquisition-related artifacts in electrophysiological recording
AssigneeCochlear Limited
InventorsRyan Orin Melman, Justin James Gilmour, Alex von Brasch, Todd Lupton
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Abstract
Aspects presented herein are directed to techniques for eliminating acquisition related artifacts in electro-physiological recording. In order to eliminate artifacts in neural response recordings, a pair of recordings is made with, respectively, inverted and non-inverted polarity at one pair of electrodes. An average of the two recordings will eliminate the acquisition artifact without the need for an extra recording, such as a baseline.
Claims21
A method of measuring an in vivo electrical potential, the method comprising:
- applying at least a first electrical stimulus to at least one stimulating electrode of an implant;
- acquiring, via a set of recording electrodes, a first trace corresponding to one or more signals evoked in response to the at least first electrical stimulus during one or more first recording probe epochs during which the set of recording electrodes have a first polarity;
- changing a polarity of the set of recording electrodes from the first polarity to a second polarity, wherein the second polarity is inverted relative to the first polarity;
- applying at least a second electrical stimulus to the at least one stimulating electrode of the implant;
- acquiring, via the set of recording electrodes, a second trace corresponding to one or more signals evoked in response to the at least second electrical stimulus during one or more second recording epochs during which the set of recording electrodes have the second polarity;
- and
- determining a difference between the first and the second traces, thereby reducing an acquisition artifact.
4 more elements
A system for measuring an evoked compound action potential (ECAP), the system comprising:
- an electrode array in electrical communication with a biological component, wherein the electrode array comprises a plurality of pairs of recording electrodes;
- a plurality of differential amplifiers, in electrical communication with the electrode array, whereby each electrode in a pair of recording electrodes is connected to an input of one of the differential amplifiers;
- a switching circuit in electrical communication with the differential amplifiers, and configured to invert a polarity of the inputs to one or more of the differential amplifiers;
- and
- instructions encoded in logical memory for:
- applying at least a first electrical stimulus via the electrode array, thereby generating an ECAP, wherein the ECAP comprises stimulus artifact, acquisition artifact, noise, and a target signal;
- recording, via a first pair of recording electrodes, a first trace corresponding to one or more signals evoked in response to the at least first electrical stimulus during one or more first recording probe epochs during which the first pair of recording electrodes have a first polarity;
- changing a polarity of the first pair of recording electrodes from the first polarity to a second polarity, wherein the second polarity is inverted relative to the first polarity;
- applying at least a second electrical stimulus via the electrode array;
- recording, via the first pair of recording electrodes, a second trace corresponding to one or more signals evoked in response to the at least second electrical stimulus during one or more second recording epochs during which the first pair of recording electrodes have the second polarity;
- subtracting a trace obtained during an epoch in which the first pair of recording electrodes have the first polarity from a trace obtained during a corresponding epoch in which the first pair of recording electrodes have the second polarity, and averaging the result, thereby eliminating the acquisition artifact.
8 more elements
Dependencies are inferred from the claim text.