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AssigneeInstitute of Microbiology, Chinese Academy of Sciences
InventorsLvyan Ma, Shan Yu, Huijun Wu, Shiwei Wang, Di Wang
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The present disclosure provides an inhibitor for inhibiting or disrupting biofilm and use thereof. Specifically, the present disclosure an application of a PsIG protein and a coding sequence thereof in inhibiting or disrupting a biofilm of a microorganism. The present disclosure also provides a composition and a preparation containing the PsIG protein to inhibit or disrupt a biofilm of a microorganism. The experiment shows that PsIG can effectively inhibit or disrupt a biofilm of Pseudomonas species, suggesting the great potential of PsIG in clinical and environmental fields.
A method of inhibiting formation of biofilm on a surface, comprising contacting the surface with a composition comprising a PsIG protein and at least one antimicrobial agent, wherein the PsIG protein increases the activity of the antimicrobial agent to inhibit formation of the biofilm and consists of an amino acid sequence of SEQ ID NO:
A method of disrupting a biofilm, comprising contacting the biofilm with a composition comprising a PsIG protein, wherein the PsIG protein consists of an amino acid sequence of SEQ ID NO:
Dependencies are inferred from the claim text.