Microstructure using cross-linked hyaluronic acid hydrogel, and method for producing same

A method for preparing microstructures formed from crosslinked hyaluronic acid hydrogels and non-crosslinked hyaluronic acid comprising the following steps:

• (a) supplying a mixture of crosslinked hyaluronic acid hydrogel and non-crosslinked hyaluronic acid into a micro-mold;
• (b) injecting the mixture into the micro-mold cavities;
• and
• (c) separating the micro-mold and the mixture to form a microstructure,
• wherein the microstructure provides mechanical properties appropriate for skin penetration and is selected from the group consisting of microneedle, microblade, microknife, microspike, microprobe, microbarb, microarray, and microelectrode, and
• wherein the weight ratio of the non-crosslinked hyaluronic acid to the crosslinked hvaluronic acid hydrogels is 1:1 to 10:1 and the solid content of crosslinked hyaluronic acid hydrogels is equal to or below 15% (w/v) in the microstructure.