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US 10,483,096 B2Granted
Device and method for analysis of biofluids by ion generation using wetted porous material
AssigneeIndiana University Research and Technology Corporation
InventorsNicholas Manicke, Chengsen Zhang
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Abstract
The present disclosure provides a mass spectrometry cartridge and methods of use thereof.
Claims34
A mass spectrometry cartridge comprising:
- a sample holder;
- a base;
- a solid phase extraction column, wherein the solid phase extraction column is disposed within the sample holder;
- and
- a first absorbent unit, wherein the first absorbent unit is configured for use with a mass spectrometer.
2 more elements
A method for analyzing a sample comprising:
- adding a sample to a cartridge, wherein the cartridge comprises
- a sample holder,
- a base,
- a solid phase extraction column, wherein the solid phase extraction column is disposed within the sample holder,
- a first absorbent unit, wherein the first absorbent unit is configured for use with a mass spectrometer, and
- a second absorbent unit disposed within the base;
- disposing the sample holder in a first extraction position, in which the solid phase extraction column is disposed above the second absorbent unit;
- disposing the sample holder in a second elution position, in which the solid phase extraction column is disposed above the first absorbent unit;
- positioning the first absorbent unit in front of a mass spectrometer pressure inlet;
- applying an electrical potential to the first absorbent unit;
- and
- analyzing the sample by mass spectrometry.
9 more elements
A method for analyzing a sample, comprising:
- (i) adding a sample to a cartridge, wherein the cartridge comprises
- (a) a sample holder,
- (b) a base,
- (c) a solid phase extraction column, wherein the solid phase extraction column is disposed within the sample holder,
- (d) a solvent port, wherein the solvent port is disposed within the sample holder, and
- (e) an absorbent unit, wherein the absorbent unit is configured for use with a mass spectrometer;
- (ii) adding a solvent to the solvent port;
- (iii) positioning the absorbent unit in front of mass spectrometer pressure inlet;
- (iv) applying an electrical potential to the absorbent unit;
- and
- (v) analyzing the sample by mass spectrometry.
8 more elements
A mass spectrometry cartridge, comprising:
- a sample holder;
- a base;
- a solid phase extraction column, wherein the solid phase extraction column is disposed within the sample holder;
- a solvent port, wherein the solvent port is disposed within the sample holder;
- and
- an absorbent unit, wherein the absorbent unit is configured for use with a mass spectrometer.
3 more elements
Dependencies are inferred from the claim text.