Optical resonator diagnostic device and methods of use

A diagnostic device fabricated in silicon, the diagnostic device comprising:

• an array of optical nanobeam resonators made of silicon, wherein at least one optical nanobeam resonator of the array of optical resonators comprises a capture agent located at a binding site;
• an optical waveguide made of silicon, the optical waveguide configured for coupling coherent light into one or more optical nanobeam resonators in the array of optical nanobeam resonators;
• and
• at least one detector optically coupled to the at least one optical resonator and configured to detect:
• a) a first resonant wavelength generated by the at least one optical nanobeam resonator when no binding reaction is present at the corresponding binding site, and b) a second resonant wavelength generated by the at least one optical nanobeam resonator upon undergoing a change in refractive index when a binding reaction is present at the corresponding binding site,
• wherein each nanobeam optical resonator comprises a substantially circular hole on a surface of the optical waveguide.