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US 10,481,145 B1Granted
Devices and methods for measuring blood coagulation
AssigneeUniversity of South Florida
InventorAnna Pyayt
Life of this patent
Estimating the term…
Abstract
In one embodiment, a device for measuring blood coagulation includes a substrate having a surface, an optical waveguide provided on the surface of the substrate, the waveguide having a tip, and means for spatially separating objects from the tip of the waveguide.
Claims13
A whole blood coagulation measurement device, comprising:
- a single substrate made from a single piece of a silicon material and having a top surface;
- an optical waveguide made of a silicon material that extends across the top surface of the substrate, the optical waveguide having an end that forms a waveguide tip, the optical waveguide comprising a primary branch and secondary branch that is coupled to the primary branch;
- spacer members provided on the top surface of the substrate along opposed lateral sides of the waveguide that are sized and configured to shield the waveguide tip from red blood cells contained in whole blood deposited on the measurement device while enabling plasma contained in the whole blood to reach the waveguide tip, wherein a top surface of the waveguide is exposed between the spacer elements so as to provide space for the plasma to reach the waveguide tip;
- a light source provided on the top surface of the substrate that is coupled to the primary branch;
- and
- a light detector provided on the top surface of the substrate that is couple to the secondary branch.
3 more elements
A whole blood coagulation measurement device configured as a three-dimensional on-chip photonic circuit, the measurement device comprising:
- a single planar substrate made from a single piece of a silicon material and having a top surface;
- an optical waveguide made of a silicon material that extends across the top surface of the planar substrate, the optical waveguide having an index of refraction that is greater than an index of refraction of the planar substrate, the optical waveguide comprising a primary branch and a secondary branch that is coupled to the primary branch, the primary branch having an end that forms a waveguide tip;
- spacer members provided along opposed lateral sides of the optical waveguide and formed on the top surface of the substrate, the spacer members defining a vertical passage between them in which a top surface of the waveguide is exposed, wherein the spacer members physically isolate the waveguide tip from red blood cells contained in whole blood deposited on the measurement device while enabling plasma contained in the whole blood to reach the waveguide tip, the spacer members comprising blocks of material deposited on the top surface of the substrate, the material having an index of refraction that is lower than the index of refraction of the optical waveguide;
- a light source provided on the top surface of the substrate that is coupled to the primary branch;
- and
- a light detector provided on the top surface of the substrate that is couple to the secondary branch.
3 more elements
Dependencies are inferred from the claim text.